Description:

It is a fixed-dose combination containing Amlodipine and Atenolol. Amlodipine is a dihydropyridine calcium antagonist, Atenolol is a cardio-selective beta-blocker,

Indications:

Essential hypertension, Angina pectoris & hypertension as co-existing diseases, Post Myocardial Infarction.

Amlodipine inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle. It has a greater effect on vascular smooth muscle than on cardiac muscle. Atenolol causes a reduction in blood pressure by lowering cardiac output, decreasing the plasma renin activity and sympathetic outflow from CNS