Composition :?Napro-A Plus 375 tablet : Naproxen BP 375 mg & Esomeprazole BP 20 mg. \n \nNapro-A Plus 500 tablet : Naproxen BP 500 mg & Esomeprazole BP 20 mg. \n \nIndications :?Napro-A Plus (Naproxen & Esomeprazole) is indicated for the treatment of the signs and symptoms of osteoarthritis (OA), rheumatoid arthritis (RA) and ankylosing spondylitis (AS) and to decrease the risk of developing gastric ulcers in patients at risk for developing NSAID-associated gastric ulcers. \n \nDosage & Administration :?The usual recommended dose for Napro-A Plus : \n

\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n

Recommended Strength	Medical Condition	Recommended (and Maximum) \n \nDose per day
Napro-A Plus 375	Osteoarthritis, Rheumatoid Arthritis, \n \nAnkylosing Spondylitis and Dysmenorrhoea	Twice daily
Napro-A Plus 500

\n  \n \nThe tablet must be swallowed whole with water but not be split, chewed, crushed or dissolved. Napro-A Plus should be taken at least 30 minutes before meal. \n \nGeriatric use (>65 years) \n \nPatients older than 65 years and frail or debilitated patients are more susceptible to a variety of adverse reactions from NSAIDs. The incidence of these adverse reactions increases with dose and duration of treatment. For such patients, to minimize the potential risk for an adverse event, the lowest effective dose should be used for the shortest possible duration. \n \nPatients with renal impairment \n \nIn patients with mild to moderate renal impairment Naproxen / Esomeprazole should be used cautiously and renal function should be monitored closely. This preparation is contraindicated in patients with severe renal impairment or deteriorating renal disease. \n \nPatients with hepatic impairment \n \nIn patients with mild to moderate hepatic impairment Naproxen / Esomeprazole should be used cautiously and hepatic function should be monitored closely. This preparation is contraindicated in patients with severe hepatic impairment. \n \nChildren (<18 years) \n \nNaproxen-Esomeprazole is not recommended for use in children under 18 years of age.