Disys^??Plus

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Valsartan + Hydrochlorothiazide

\nDescription \nValsartan blocks the vasoconstrictor and aldosterone-secreting effects of angiotensin II by selectively blocking the binding of angiotensin II to the AT1 receptor in many tissues, such as vascular smooth muscle and the adrenal gland. Its action is therefore independent of the pathways for angiotensin II synthesis. \n \nHydrochlorothiazide is a thiazide diuretic. It affects the renal tubular mechanisms of electrolyte reabsorption, directly increasing the excretion of sodium and chloride. Indirectly, the diuretic action of Hydrochlorothiazide reduces plasma volume, with consequent increases in plasma renin activity, increases in aldosterone secretion, increases in urinary potassium loss, and decrease in serum potassium. The renin-aldosterone link is mediated by angiotensin II, so coadministration of an angiotensin II receptor antagonist (Valsartan) tends to reverse the potassium loss associated with thiazide diuretics. \n \nIndications \nHypertension \nDisys^??Plus (Valsartan & Hydrochlorothiazide) is indicated for the treatment of hypertension. \n \nHeart Failure \nDisys^??plus are indicated for the treatment of heart failure (NYHA class II-IV) in patients who are intolerant of angiotensin converting enzyme inhibitors. In a controlled clinical trial, Valsartan significantly reduced hospitalizations for heart failure. \n \nSupply \nDisys^??Plus 80/12.5mg Tablet: Each box contains 30s tablets in Alu-Alu blister pack