Description:
Gingoba-100 (Ginkgo Biloba) is one of the 10 best selling alternative and complementary Drugs in all over the Europe including united states. There are over 120 published clinical studies on Ginkgo Biloba, primarily from Europe. Ginkgo biloba extract is prepared from the leaves of the Ginkgo tree. The most common formulation is prepared by concentrating 50 parts of the crude leaf to prepare one part of extract. The active constituents in Ginkgo Biloba are Flavone glycosides and Terpene lactones. The Standardized preparation of Ginkgo Biloba extract is EGB 761, Containing 24% flavone glycoside and 6% Terpene lactones.

 

Recommended Dosage and Administration:
The mechanism of action of Tablet Gingoba100 is proved to be produced by its function as a neuroprotective agent, an antioxidant, a free radical Scavenger, a membrane stabilizer and an inhibitor of platelet activating factor via the terpene ginkgolide B. The pharmacologic effects include following endothelium relaxation mediated by inhibition of 3, cyclic GMP (Guanosine Monophosphate) phosphodiestrase, inhibition of age related loss muscarinergic cholinoceptors and a -adrenoceptors and stimulation of choline uptake in the hippocampus. Gingoba-100 (Ginkgo Biloba extract) also has been shown to inhibit beta amyloid deposition.

Actions and Uses:
Circulatory- Gingoba 100 increases circulation to both the brain and extremities of the body. In addition to inhibit platelet stickiness, Gingoba regulates the tone and elasticity of blood vessels, makes circulation more efficient.

Cognitive- Recently, the ginkgo extract EGB 761 was found to increase alpha wave and decrease theta wave activity following oral intakes of 120 or 240 mg in healthy volunteers. These brain wave changes indicate that EGB 761 is capable of improving cognitive function as demonstrated in increased mental sharpness, concentration, and memory.

Antioxidant properties- Gingoba 100
(GBE) has antioxidant actions in the brain, retina of the eye, and the cardiovascular system. One double blind study found that Gingoba could help people with macular degeneration, an oxidation-related disorder causing decreased or lost vision. It's antioxidant activity in the brain and central nervous system to help to prevent agerelated declines in brain function.

Antidepressant- One double blind study in Germany found that elderly depressed people with mild dementia (who were not responding to antidepressant medications) responded well to Gingoba-100 (GBE).

Nerve protection and PAF inhibition- One of the primary protective actions of ginkgolides is their ability to inhibit a substance known as platelet-activating factor (PAF), a mediator released from cells that causes platelets to aggregate ( clump together).

Tinnitus and balance- Gingoba 100 inproved tinnitus (ringing in the ears) and balance problems related to inner ear , an important part of maintaining balance. Double blind studies have confirmed the benefit of Gingoba 100 (GBE) for people with tinnitus or vertigo.

Indications:
Acute Cerebro-Vascular Accidents (Strokes): Ischaemic strokes due to cerebral thrombosis, cerebral embolism, acute circulatory disorder, hypertensive crisis; the acute cardiovascular disorders, ischaemic neurological deficit (RIND), complete stroke (CS), multi infarct dementia, cerebral arteriosclerosis,hypertensive encephalopathy, post-apoplectic conditions with the background of haemorrhagic strokes etc.

Gerontology: For relief of psychosomatic symptoms in the elderly due to cerebral insufficiency eg. forgetfulness, memory disturbances, slow thinking, lack of concentration, dizziness, mood instability, aphasia, sleep disturbances, Vasovegetative symptoms of menopausal syndrome etc.

Ophthalmology: Vascular disorders of the choroid and retina due to arteriosclerosis. Vasospasm, macula degenerations, arterial or venous thrombosis or embolism and glaucoma secondary to the above mentioned disorders.

Otology: For the treatment of impaired hearing of vascular or toxic (iatrogenic) origin presbycusis. Meniere's disease, cochleovestibular neuritis, tinnitus and dizziness of labirynth origin.

Peripheral arterial diseases: The world health organization has recommended the use of Ginkgo Biloba in Raynaund's disease, Intermittent Claudication, Acrocyanosis and post phlebitic syndrome.

Sexual Dysfunction: Ginkgoba-100 (Ginkgo Biloba ) is a proven circulatory accelerator agent both cerebral & peripheral. So it has got capabilities to eliminate successfully the vascular related erectile dysfunction of the men and loss of libido of the women. So it prevents impotency, Sexual weakness and pre-mature ejaculation.

Interaction:
The chemically active ginkgolides present in the extract, specifically the ginkgolides B comporent, act to reduce the clotting time of blood and to interact with anti thrombotic medicines, including aspirin.

Contraindication and Precaution:
*Hypersensitivity to Gingoba 100, terpene lactone, flavone glycoside.
* Exceeding daily dose of 240 mg may result in restlessness, diarrhea and mild gastrointestinal disorders.
*Should be avoided when taking anticoagulant to avoid over-thinning of blood and hemorrhaging.
*Should be avoided two days before and one to two weeks after surgery to avoid bleeding complications.
Storage:
Keep in cool preferably lower than 25 C, dry place, protected from light and heat.
 

Supply:
30 tablets in two blisters pack in a box.

References:
 Hanrahan, C. Ginkgo biloba. Gale encyclopedia of alternative medicine. Gale group 2001

 Drieu K. Preparation and definition of Ginkgo biloba extract. In: Rokan (Ginkgo biloba): Recent Results of Pharmacology and Clinic, ed. EW Fungeld. Berlin: SpringerVerlag, 32-36.

 lung, F Mrowietz C, et al. Effect of Ginkgo biloba on fluidity of blood and peripheral microcirculalioll
ill volulll --rs. Arzneim-Forsch Drug Re::. 1990; 40: 5S90-93.

 ltil TM, et al. Central nervous system effects of ginkgo biloba, a plant extract. AM.I Therapeutics 1996; 3:63-73.

 Blurne 1, et al. Placebo-controlled doubleblind study of the effectiveness of ginkgo biloba special extract EGb 761 in trained patients with intermittent claudication. Vasa 1996; 25(3): 265-74, Switzerland.

 Kanowski S, el al. Proofofefticacy of the ginkgo biloba special extract EGb 761 in outpatients suffering, from mild to moderate primary degenerative dementia of the Alzheimer type or multi- infarct dementia. Pharmacopsychiatry 1996; 29: 47-56.

Kreiglstein J Neuroprotective properties of Ginkgo biloba - constituents. Zeitsehrift Phytother 1994; 15:92-96.

 Bruno C, Cuppini R, et al. Regeneration of motor nerves in bilobalide-treated rats. Planta
Medica 1993;59:302-7.

 Le Bars PL, Katz tvlM, Berma.'1 N, et al. A placebo -::: ontrolled, double-blind, randomized
trial of an v tract of Ginkgo biloba for dementia. Norili Amen in L., :_ h nup. ,lama 1997; 278: 1327-32.
biloha - constituents. Zeitschrift Phytother 1994; 15:92-96.

 Bruno C, Cuppini R, et a]. Regeneration of motor nerves in hilobalide-treated rats. Plania
Medica 1993,-59:302-7.

 Le Bars PL, Katz tvlM, Berma.'1 N, et al. A placebo -::: ontrolled, double-blind, randomized trial of an extract of Ginkgo biloba for dementia. North American Egb
Study Group. Jama 1997; 278: 1327-32.