\n \nRecommended dose in adults 18 years of age or older for the treatment of chronic hepatitis B infection: The recommended dose is 300 mg once daily with or without food. However, it is generally recommended to be taken with a meal to improve bioavailability. \n \nUsual adult dose for HIV infection: 300 mg orally once a day. \n \nPatients with renal impairment: No dosage adjustment is necessary for patients with mild renal impairment (creatinine clearance 50-80 mL/min). Since tenofovir is principally eliminated by the kidney, in the case of severe renal impairment, including cases of acute renal failure and Fanconi syndrome- dosage adjustment is required in all patients with creatinine clearance <50 ml/min, as detailed in table. \n
\n \n \n | \nCreatinine clearance (mL/min) | \nHemodialysis patients | \n
\n \n>=50 | \n30-49 | \n10-29 | \n
\n \nRecommended dose | \n300 mg every 24 hours | \n300 mg every 48 hours | \n300 mg every 72 to 96 hours | \nEvery 7 days or after approximately 12 hours of dialysis | \n
\n \n
\nIn hepatic impairment: No dose adjustment is required in patients with hepatic impairment. \n \n