Administration of Tecavir with food decreases absorption and so it should be taken in an empty stomach (at least 2 hours before or 2 hours after meal). Adult over 16 years, not previously treated with nucleoside analogues: 0.5 mg once daily. Adult over 16 years with lamivudine or telbivudine resistant chronic hepatitis B: 1 mg once daily. Dose adjustment in renal impairment: Dose adjustment is recommended for patients with creatinine clearance <50 ml/min including patients on hemodialysis or continuous ambulatory peritoneal dialysis (CAPD) as shown in the following table. \n
\n \n \nDosing interval adjustment of Tecavir in patients with renal impairment | \n
\n \nCreatinine clearance \n(ml/min) | \n≥50 | \n30 to <50 | \n10 to <30 | \n<10 Hemodialysis or CAPD | \n
\n \nRecommended dose | \n0.5 mg every 24 hours | \n0.5 mg every 48 hours | \n0.5 mg every 72 hours | \n0.5 mg every 7 days | \n
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