Naproxen is a preparation of naproxen, which is a non-steroidal anti-inflammatory agent. The drug exhibits anti-inflammatory, analgesic and antipyretic activity. Naproxen is an inhibitor of prostaglandin synthesis.
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Presentation:
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Napro Tablet: Each tablet contains Naproxen BP 250 mg. Napro-500 Tablet: Each tablet contains Naproxen BP 500 mg.
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Indication:
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Napro is indicated in inflammatory rheumatic diseases, rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, in soft tissue rheumatism & musculoskeletal disorders, acute gout, dysmenorrhoea etc.
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Dosage & Administration:
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1. Rheumatic disorders: the usual initial dose of naproxen is 250 mg twice daily adjusted to 500 mg to 1000 mg daily in 2 divided doses. 2. Juvenile arthritis: A dose of 10 mg/kg body weight daily in 2 divided doses is used for children over 5 years of age. 3. Acute gout: An initial dose of 750 mg followed by 250 mg every 8 hours. 4. Dysmenorrhoea: 500 mg may be given initially followed by 250 mg in every 6-8 hours.
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Contrainidications:
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History of asthma attacks or urticaria triggered by acetylsalicylic acid or other prostaglandin synthesis inhibitors.
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Warning & Precautions:
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Use of Naproxen should be avoided in patients with gastrointestinal disorders and gastro-duodenal ulcer. In case of severe hepatic or renal damage or disturbance of cardiac function a close medical surveilance is indicated. Blood counts including platelet counts, as well as monitoring of hepatic and renal functions are recommended, particularly in patients under long-term therapy.
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Side effects:
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Naproxen is generally well tolerated, but occasionally patient may complain gastric discomfort, nausea & dizziness. In exceptional cases, very sensitive patients may suffer from gastro-intestinal bleeding, skin rashes, thrombocytopenia.
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Drug interaction:
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Antacid: The absorption of naproxen can be altered by antacids. Aspirin: Plasma concentration of Naproxen can be reduced when aspirin is given concomitantly, this appeared to be due to increased exeretion of naproxen. Diuretics: Naproxen diminish the effect of frusemide. Probenecid: It increase the plasma concentration of Naproxen.
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Packing:
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Napro Tablet: Each box contains 50's tablets in blister pack. Napro-500 Tablet: Each box contains 30's tablets in blister pack.