Apuldon Tablet: Each tablet contains Domperidone Maleate BP equivalent to Domperidone 10 mg. Apuldon Suspension: Each 5 ml contains Domperidone BP 5 mg. Apuldon Paediatric Drops: Each ml contains Domperidone BP 5 mg. Apuldon-15 Suppository: Each suppository contains Domperidone BP 15 mg. Apuldon-30 Suppository: Each suppository contains Domperidone BP 30 mg.
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Indication:
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1. Stimulation of gut mobility: Non-ulcer dyspepsia, esophageal reflux, reflux esophagitis & gastritis, diabetic gastroparesis. 2. Prevention and symptomatic relief from acute nausea & vomiting in adults from any cause but especially in cytotoxic therapy & radiotherapy, associated with migraine attacks (in combination with analgesics) and L-dopa and bromocriptine treatment for Parkinsonian patients. 3. Functional dyspepsia.
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Dosage & Administration:
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The recommended oral dose for: Adults: 10-20 mg every 4-8 hours daily. Children (2-12 years): 0.2-0.4 mg/kg body weight (0.4-0.8ml paediatric drops/10 kg) every 4-8 hours daily. Suppository: Adult and child body weight over 35 kg: 60 mg twice daily; child 15-35 kg (nausea and vomiting only): 30 mg twice daily. Note: Both tablet & suspension should be taken 15-30 minutes before a meal. For acute nausea & vomiting maximum period of treatment is 12 weeks.
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Contrainidications:
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Patients with a known allergy to Domperidone or Domperidone Maleate or any inactive ingredient of the product.
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Warning & Precautions:
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In case of children, treatment with Apuldon should be continued with caution because there may be increased risk of extra-pyramidal reactions in young children.
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Side effects:
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Apuldon may produce hyperprolactinemia which may cause galactorrhea & breast enlargement, soreness and reduced libido. It may rarely cause dry mouth, thirst, headache, nervousness, drowsiness, diarrhea, skin rash and itching.
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Drug interaction:
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Apuldon may reduce the hypoprolactinemic effect of bromocriptine. The effect of antimuscarinics & opioid analgesics may antagonize Apuldon on GI function.
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Use in special groups:
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Use in pregnancy: The safety of this drug has not been established for pregnant women. So it is not recommended during pregnancy. Use in lactation: Apuldon may precipitate galactorrhea and improve postnatal lactation, which is secreted in breast milk but in very small quantities insufficient to be considered harmful.
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Packing:
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Apuldon Tablet: Each box contains 100 tablets in blister pack. Apuldon Suspension: Each bottle contains 60 ml suspension. Apuldon Paediatric Drops: Each bottle contains 15 ml drops. Apuldon-15 Suppository: Each box contains 10 suppositories in PVC / PE strip pack. Apuldon-30 Suppository: Each box contains 10 suppositories in PVC / PE strip pack.