IV/IM Injection Hypnofast - 5 mg/ml (1 ml)
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\nHypnofast 7.5 tablet: Each tablet contains Midazolam BP 7.5 mg (as Midazolam Maleate).
\nHypnofast 15 mg/3 ml Injection: Each 3 ml ampoule contains Midazolam BP 15 mg (as Midazolam Hydrochloride).
\nHypnofast 5 mg/1 ml Injection: Each 1 ml ampoule contains Midazolam BP 5 mg (as Midazolam Hydrochloride).
\nHypnofast 5 mg/5 ml Injection: Each 5 ml ampoule contains Midazolam BP 5 mg (as Midazolam Hydrochloride).
\n \nDescription
\nMidazolam is a sleep inducing agent characterized by a rapid onset and short duration of action. It also exerts an anxiolytic, anticonvulsant and muscle-relaxant effect.
\n \nIndications
\nShort-term treatment of insomnia.
\n \nSedation in premedication before surgical or diagnostic procedures.
\n \nDosage & Administration
\nOral dosage: For adults 7.5-15 mg daily. In elderly and debilitated patients, the recommended dose is 7.5 mg. In premedication, 15 mg of Midazolam should be given 30-60 minutes before the procedure.
\n \nIntravenous administration:
\nEndoscopic or Cardiovascular Procedures
\nIn healthy adults the initial dose is approximately 2.5 mg. In cases of severe illness and in elderly patients, the initial dose must be reduced to 1 to 1.5 mg.
\n \nInduction of Anesthesia
\nThe dose is 10-15 mg I. V.
\n \nIntramuscular administration:
\nAdult: 0.07-0.1 mg/kg bodyweight i. m. Usual dose is about 5 mg.
\nChildren: 0.15-0.20 mg/kg.
\nElderly and debilitated patients: 0.025-0.05 mg/kg
\n \nRectal administration in children:
\nFor preoperative sedation, rectal administration of the ampoule solution (0.35-0.45 mg/kg) 20-30 min before induction of general anesthesia.
\nSide Effects
\nAt the start of therapy, drowsiness during daytime, confusion, fatigue, headache and muscle weakness may occur which usually disappear with repeated administration. Following parenteral (IV or IM) administration of Midazolam, fluctuations in vital signs have been noted including respiratory depression, apnoea, variations in blood pressure and pulse rate.
\n \nPrecautions
\nMidazolam IV should be administered very slowly.
\n \nUse in Pregnancy & Lactation
\nMidazolam should be avoided during pregnancy unless there is no safer alternative. Since Midazolam passes into breast milk, it should not be administered to breast-feeding mothers.
\n \nOver Dose
\nExtreme overdosage may lead to coma, areflexia, cardiorespiratory depression and apnea. The effects of overdosage can be controlled with benzodiazepine antagonist flumazenil.
\n \nCommercial Pack
\nHypnofast 7.5 tablet: Each box contains 3 blister strips of 10 tablets.
\nHypnofast 15 mg/3 ml Injection: Each box contains 1 ampoule of 3 ml.
\nHypnofast 5 mg/1 ml Injection: Each box contains 1 ampoule of 1 ml.
\nHypnofast 5 mg/5 ml Injection: Each box contains 1 ampoule of 5 ml.
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