Methylprednisolone USP \n \nComposition :?Depomed 500mg IV/IM Injection :?Each vial contains sterile powder of Methylprednisolone 500mg as Methylprednisolone Sodium Succinate USP IV/IM Injection. \n \nIndications :?It is indicated for the treatment of?1. Endocrine Disorders:Primary or secondary adrenocortical insufficiency,?congenital adrenal hyperplasia, nonsuppurative thyroiditis,?hypercalcemia associated with cancer?2. Rheumatic Disorders:?Rheumatoid arthritis, including juvenile rheumatoidarthritis, ankylosing spondylitis, acute and subacute bursitis,?synovitis of osteoarthritis, acute non-specific tenosynovitis,?post-traumatic osteoarthritis, psoriatic arthritis, epicondylitis, acute gouty arthritis?3. Collagen Diseases:Systemic lupus erythematosus systemic dermatomyositis, acute rheumatic carditis?4. Dermatologic Diseases:?Bullous dermatitis herpetiformis, severe erythema multiforme, severe seborrheic dermatitis, exfoliative dermatitis, mycosis fungoides, pemphigus, severe psoriasis?5. Allergic States:?Seasonal or perennial allergic rhinitis, drug hypersensitivity reactions, serum sickness, contact dermatitis, bronchial asthma, atopic dermatitis?6. Ophthalmic Diseases:?Allergic corneal marginal ulcers, herpes zoster ophthalmicus, anterior segment inflammation,?sympathetic ophthalmia, keratitis, optic neuritis, allergic conjunctivitis chorioretinitis, iritis and iridocyclitis?7. Respiratory?Diseases:?Symptomatic sarcoidosis, berylliosis, loeffler's syndrome not manageable by other means, fulminating or disseminated pulmonary tuberculosis when used concurrently with appropriate antituberculous chemotherapy, aspiration pneumonitis?8. Hematologic Disorders:?Idiopathic thrombocytopenic purpura in adults, secondary thrombocytopenia in adults, acquired (autoimmune) hemolytic anemia, erythroblastopenia (RBC anemia), congenital (erythroid) hypoplastic anemia?9. Neoplastic Diseases:?For palliative management of: Leukemias and lymphomas in adults, acute leukemia of childhood?10. Edematous States:?To induce a diuresis or remission of proteinuria in the nephrotic syndrome, \n \nwithout uremia, of the indiopathic type or that due to lupus erythematosus?11. Gastrointestinal Diseases:?Ulcerative colitis, regional enteritis?12. Nervous System:?Acute exacerbations of multiple sclerosis, etc. It is also indicated for the treatment of terminal cancer, organ transplantation, cardiovascular condition etc. \n \nDosage and administration :?It is depending on the specific disease entity being treated in the following conditions : \n
Indications | \nDosage | \n
Adjunctive therapy in?life-threatening \n \nconditions | \nAdminister 30 mg/kg IV over a period of at least 30 minutes.?Dose may be repeated every 4 to 6?hours for up to 48 hours. | \n
Acute respiratory distress syndrome (ARDS) | \nInitially 2-3mg/kg/day IV, decreasing after 7 days. | \n
Rheumatic disordersunresponsive to standard \n \ntherapy (or during exacerbation episodes). | \nAdminister either regimen as IV pulse dosing over at least 30 minutes. The regimen may be repeated if \n \nimprovement has not occurred within a week after therapy.?1 g/day for 1 to 4 days, or 1 g/month for 6 months. | \n
Systemic Lupus Erythematosus (SLE)unresponsive \n \nto standard therapy (or during exacerbation episodes). | \nAdminister 1 g/day for 3 days as IV pulse dosing over at least 30 minutes.?The regimen may be \n \nrepeated if improvement has not occurred within a week after therapy, or as the patient's condition dictates. | \n
Multiple sclerosisunresponsive to standard \n \ntherapy (or during exacerbation episodes). | \nAdminister 1 g/day for 3 or 5 days as IV pulse dosing over at least 30 minutes.?The regimen may be \n \nrepeated if improvement has not occurred within a week after therapy, or as the patient's condition dictates. | \n
Acute spinal cord injury | \nTreatment should begin within 8 hours of injury. \n \nWithin 3 hours of injury :?Bolus 30 mg/kg in 50ml IV fluid over 15 minutes, wait 45 minutes, then \n \ncontinuous infusion of 5.4 mg/kg/hour for 23 hours. \n \n3-8 hours after injury :?Bolus 30mg/kg in 50ml IV fluid over 15 minutes, wait 45 minutes, then \n \ncontinuous infusion of 5.4 mg/kg/hour for 47 hours. \n \nThere should be a separate intravenous site for the infusion pump. | \n
Edematous states,?such as?glomeulonephritis \n \nor lupus nephritis,unresponsive to standard \n \ntherapy (Or during exacerbation episodes). | \nAdminister either regimen as IV pulse dosing over at least 30 minutes. The regimen may be repeated if \n \nimprovement has not occurred within 1 week after therapy, or as the patient's condition dictates.?30 \n \nmg/kg every other day for 4 days or 1 g/day for 3, 5 or 7 days. | \n
Pemphigus & Bullous Pemphigoid | \nAdminister either regimen as IV pulse dosing over at least 30 minutes. The regimen may be repeated if \n \nimprovement has not occurred within 1 week after therapy, or as the patient's condition dictates.?30 \n \nmg/kg every other day for 4 days or 1 g/day for 3, 5 or 7 days. | \n
In other indications | \nInitial dosage will vary from 10 to 500 mg depending on the clinical problem being treated.?The \n \nlarger dosage may be required for short-term management of severe, acute conditions. The initial dose \n \nshould be given intravenously over a period of at least 5 minutes (e.g up to 250mg) to at least 30 minutes \n \n(e.g doses exceeding 250mg). Subsequent doses may be given intravenously or intramuscularly at \n \nintervals dictated by the patients response and clinical conditions. | \n
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