\n \nOral: Adolescents and adults: \n
\n \n \nInfections | \nDosage | \nDuration (days) | \n
\n \nPharyngitis/tonsillitis | \n250 mg b.i.d. | \n10 | \n
\n \nAcute bacterial maxillary sinusitis | \n250 mg b.i.d. | \n10 | \n
\n \nAcute bacterial exacerbation of chronic bronchitis | \n250-500 mg b.i.d. | \n10 | \n
\n \nSecondary bacterial infections of acute bronchitis | \n250-500 mg b.i.d. | \n5-10 | \n
\n \nUncomplicated skin and skin structure infections | \n250-500 mg b.i.d. | \n10 | \n
\n \nUncomplicated urinary tract infections | \n125-250 mg b.i.d. | \n7-10 | \n
\n \nGonorrhoea | \n1000 mg once daily | \nSingle dose | \n
\n \nEarly Lyme disease | \n500 mg b.i.d. | \n20 | \n
\n \nMDR Enteric Fever | \n500 mg b.i.d. | \n14 days | \n
\n \n
\nChildren:(over 3 months) Pharyngitis/tonsillitis; 20 mg/day in two divided doses for 10 days. Acute otitis meida, acute bacterial maxillary sinusitis & impetigo: 30 mg / kg /day in two divided doses for 10 days. Parenteral: Adults: 750 mg every 6-8 hours; 1.5 g every 6-8 hours. In severe infections: single doses over 750 mg intravenous route only. Children: usual dose 60 mg / kg daily (range 30-100 mg/kg daily) in 3-4 divided doses (2-3 divided doses in neonates) Prophylaxis: 1.5 g IV/IM with induction of anesthesia followed by 750 mg IM at 8 hours & 16 hours or three times daily for a further 24-48 hours. Gonorrhoea : 1.5 g as a single dose by intramuscular injection (divided between 2 sites). Surgical prophylaxix: 1.5 g IV at induction may be supplemented with 750 mg IM every 8 hours for further 24-48 hours (cardiac, pulmonary, oesopheal & vascular operations). Meningitis: 3g intravenously every 8 hours. Chlid:200-240 mg/kg daily (in 3-4 divided doses) reduced to 100 mg/kg daily after 3 days or on clinical improvement. Neonate: 100 mg/kg daily reduced to 50 mg/kg daily. Preparation of Solutions for Oral Suspension & Intramuscular/Intravenous Injections : Suspension : Shake the bottle before adding water. Then add 35 ml boiled and cooled water to the bottle to produce 70 ml suspension. Then continue shaking the bottle unit the powder dissolves properly. For 750 mg intramuscular injection: Add 3 ml water for injection BP to vial and then shake gently to dissolve. For 750 mg intravenous injection: Add 6 ml water for injection BP to vial and then shake gently to dissolve. For 1.5 g intravenous injection: Add 16 ml Water for injection BP to vial and then shake gently to dissolve. Reconstituted injections retain their potency for 24 hours at room temperature or for 48 hours if refrigerated at 5°C. \n \n