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Injection Glyset Mix - 100 IU/ml (3 ml)

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About the Product

Full Description

Presentation
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Glyset Mix 100 IU: Each ml suspension contains 100 IU (equivalent to 3.50 mg) Insulin Aspart (rDNA) BP as 30%
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soluble Insulin Aspart and 70% protamine-crystallised Insulin Aspart.
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Description
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Glyset Mix (insulin aspart protamine and insulin aspart) is a sterile suspension of human insulin analog containing? 30% soluble insulin aspart and 70% protamine-crystallised insulin aspart. Glyset Mix is a blood glucose lowering agent with an earlier onset and an intermediate duration of action. Insulin Aspart is homologous with regular human insulin with the exception of a single substitution of the amino acid proline by aspartic acid in position B28, and is produced by recombinant DNA technology.
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Indications
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Glyset Mix is an insulin analog indicated to improve glycemic control in patients with diabetes mellitus.
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Dosage & Administration
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Dosage of Glyset Mix is individual and determined by the physician in accordance with the needs of the patient. In patients with type 2 diabetes, Glyset Mix can be given in mono therapy or in combination with oral antidiabetic drugs when the blood glucose is inadequately controlled with those oral antidiabetic drugs alone. For patients with type 2 diabetes, the recommended starting dose of Glyset Mix is 6 IU at breakfast and 6 IU at dinner (evening meal). Glyset Mix can also be initiated once daily with 12 IU at dinner (evening meal). When using Glyset Mix once daily, it is generally recommended to move to twice-daily when reaching 30 units by splitting the dose into equal breakfast and dinner doses. If twice daily dosing with Glyset Mix results in recurrent daytime hypoglycaemic episodes, the morning dose can be split into morning and lunchtime doses (thrice daily dosing). The dose should not be increased if hypoglycemia occurred within three days. Dose adjustments can be made once a week until target HbA1c is reached. In patients with type 1 diabetes the individual insulin requirement is usually between 0.5 and 1.0 IU/kg/day. Glyset Mix may fully or partially meet this requirement. When transferring a patient from biphasic human insulin to Glyset Mix, start with the same dose and regimen. Then titrate according to individual needs (according to the titration guidelines in table above). Glyset Mix can be used in elderly patients; however there is limited experience with the use of Glyset Mix in combination with OADs in patients older than 75 years For details,please see enclosed leaflet
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Side Effects
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Side effects of Insulin Aspart are hypoglycemia, allergic reactions, injection site reaction, lipodystrophy, pruritus and rash.
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Precautions
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Dose adjustment and monitoring: Blood glucose should be monitored in all patients treated with insulin. Insulin regimens should be modified cautiously and only under medical supervision.
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Use in Pregnancy & Lactation
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Pregnancy: Pregnancy category B.
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Lactation: There are no restrictions on treatment with Glyset Mix during lactation. Insulin treatment of the nursing mother should not affect the baby. However, dosage may need to be adjusted.
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Drug Interaction
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A number of drugs affect glucose metabolism and may require dose adjustment. The following substances may reduce the Insulin as well as Insulin Aspart requirements: Oral anti-diabetic products, angiotensin converting enzyme (ACE) inhibitors, disopyramide, fibrates, fluoxetine,?monoamine oxidase inhibitors, propoxyphene, pentoxifylline, salicylates and sulfonamide antibiotics. The following substances may increase the Insulin as well as Insulin Aspart requirements: Thiazides, glucocorticoids, thyroid hormones, beta-sympathomimetics, growth hormone and danazol. Beta-blockers, clonidine, lithium salts, and alcohol may either potentiate or weaken the blood glucose lowering effect of insulin.
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Over Dose
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A specific overdose for insulin cannot be defined, however, hypoglycaemia may develop over sequential stages if too high doses relative to the patient?s requirement are administered. Mild hypoglycaemic episodes can be treated by oral administration of glucose or sugary products.?Severe hypoglycaemic episodes, where the patient has become unconscious, can be treated by glucagon (0.5 to 1 mg) given intramuscularly or subcutaneously. Glucose must also be given intravenously if the patient does not respond to glucagon within 10 to 15 minutes. Upon regaining consciousness administration of oral carbohydrate is recommended for the patient in order to prevent relapse.
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Storage
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Store at 2 0C to 8 0C in a refrigerator. Do not freeze. Protect from light.
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Commercial Pack
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Glyset Mix 100 IU: Each box contains 1 glass vial of 3 ml Insulin Aspart. Each ml suspension contains 100 IU (equivalent to 3.50 mg) Insulin Aspart (rDNA) BP as 30% soluble Insulin Aspart and 70% protamine-crystallised
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Insulin Aspart.
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