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Presentation

\nTicoflex 250 tablet: Each tablet contains Naproxen BP 250 mg. \nTicoflex 500 tablet: Each tablet contains Naproxen BP 500 mg. \nTicoflex suspension: Each 5 ml suspension contains Naproxen BP 125 mg. \nTicoflex 15 gm gel: Each gram gel contains Naproxen BP 100 mg. \nTicoflex SR 500 tablet: Each SR tablet contains Naproxen BP 500 mg. \n \n

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Description

\nNaproxen is a nonsteroidal anti-inflammatory drug with analgesic and antipyretic properties. Naproxen works by reducing the levels of prostaglandins, chemicals that are responsible for pain, fever and inflammation. Naproxen blocks the enzyme that makes prostaglandins (cyclooxygenase), resulting in lower concentrations of prostaglandins. As a consequence, inflammation, pain and fever are reduced. \n \n

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Indications

\nNaproxen is indicated for its anti-inflammatory and analgesic action in the treatment of rheumatoid arthritis, osteoarthritis (degenerative arthritis), ankylosing spondylitis, juvenile rheumatoid arthritis, acute gout, acute musculoskeletal disorders, post-operative pain and dysmenorrhoea. It is also indicated in the relief of mild to moderate pain, and for the treatment of tendonitis and bursitis. \n \n

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Dosage & Administration

\nNaproxen tablet \nAdults \nFor rheumatoid arthritis, osteoarthritis and ankylosing spondylitis \nThe usual dose is 500-1000 mg per day taken in 2 doses at 12 hours intervals after meals. \nFor acute gout \n750 mg should be given initially, followed in 8 hours with 500 mg, and thereafter 250 mg at 12 hours intervals until the attack has passed. \nFor dysmennorhoea \n500 mg should be given initially, followed by 250 mg at 6-8 hour intervals for up to 5 days. \nFor analgesia and acute muscular skeletal disorders \n500 mg should be given initially, followed by 250 mg at 6-8 hour intervals. \nChildren over 5 years \nFor juvenile rheumatoid arthritis \n10mg/kg/day given as 2 divided doses at 12 hour intervals. \nSR tablet: For rheumatoid arthritis, osteoarthritis and ankylosing spondylitis \n500mg or 1000mg (500mg ? 2) SR tablet once daily (morning or evening) after meals. \nSR tablet is also indicated after the acute condition is subsided for long term use. \nNaproxen suspension \nAdults \nDosage is the same as Naproxen tablet. \nChildren over 5 years \n10 mg/kg/day given as 2 divided doses at 12 hours intervals. \nNaproxen gel \n2-6 times a day as required. \n \n

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Side Effects

\nThe most common side effects from Naproxen are rash, ringing in the ears, headaches, dizziness, drowsiness, abdominal pain, nausea, diarrhea, constipation, heartburn, fluid retention and shortness of breath. Naproxen also may cause stomach and intestinal bleeding and ulcers. \n \n

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Precautions

\nSerious GI toxicity such as bleeding, ulceration, and perforation, can occur at any time, with or without warning symptoms, in patients treated chronically with NSAID therapy. Although minor upper GI problems, such as dyspepsia, are common, usually developing early in therapy, physicians should remain alert for ulcerations and bleeding in patients treated chronically with NSAIDs even in the absence of previous GI tract symptoms \n \n

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Use in Pregnancy & Lactation

\nPregnancy: Pregnancy Category B \nNaproxen should be used during pregnancy only if the potential benefits justify the potential risks to the fetus. \nNursing mother: The Naproxen has been found in the milk of lactating women. Because of the possible adverse effects of prostaglandin-inhibiting drugs on neonates, use in nursing mothers should be avoided. \n \n

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Drug Interaction

\nNaproxen may increase the blood levels of lithium by reducing the excretion of lithium by the kidneys. Increased levels of lithium may lead to lithium toxicity. \nNaproxen may reduce the blood pressure lowering effects of blood pressure medications. \nWhen naproxen is used in combination with aminoglycosides (e.g., gentamicin) the blood levels of the aminoglycoside may increase. This may lead to more aminoglycoside-related side effects. \nIndividuals taking anticoagulants (e.g., Warfarin) should avoid naproxen because naproxen also thins the blood, and excessive blood thinning may lead to bleeding. \n \n

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Over Dose

\nNaproxen overdosage may be characterized by drowsiness, heartburn, indigestion, nausea, or vomiting. In animals 0.5 g/kg of activated charcoal was effective in reducing plasma levels of Naproxen. Hemodialysis does not decrease the plasma concentration of Naproxen. \n \n

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Commercial Pack

\nTicoflex 250 tablet: Each box contains 5 blister strips of 10 tablets. \nTicoflex 500 tablet: Each box contains 5 blister strips of 10 tablets. \nTicoflex 50 ml suspension: Each bottle contains 50 ml suspension. \nTicoflex 15 gm gel: Each tube contains 15 gm of Naproxen gel. \nTicoflex SR 500 tablet: Each box contains 3 blister strips of 10 tablets. \n \n