Infection | \nDose | \nFrequency | \n
---|---|---|
Severe infections including pneumonia, urinary tract infections, complicated intra-abdominal infections, including cases with an associated bacteremia | \n2g IV | \n12 hourly | \n
Mild to moderate urinary tract infections (uncomplicated and complicated) | \n500mg – 1g IV or IM | \n|
Mild to moderate infections including bronchitis, skin and skin-structure infections | \n1g IV or IM | \n|
Empiric treatment of febrile neutropenia | \n2g IV | \n8 hourly | \n
Surgical prophylaxis | \n2g IV | \nSingle dose | \n
Infection | \nDose & frequency | \n
---|---|
Pneumonia, urinary tract infections, and skin structure infections | \nPatients 2 months of age with body weight > 40 kg: 50 mg/kg 12 hourly for 10 days. For more severe infections, a dosage schedule of 8 hourly can be used. | \n
Empiric treatment of febrile neutropenia | \nPatients >2 months of age with body weight >40 kg: 50 mg/kg 8 hourly for 7-10 days. | \n
Experience with the use of Cefepime in paediatric patients >2 months of age is limited. A dosage of 30 mg/kg 12 hourly or 8 hourly may be considered for patients aged 1 month to 2 months. | \n|
For paediatric patients with body weight > 40 kg, adult dosing is recommended. For patients older than 12 years who are >40 kg, the dosage recommendations for younger patients >40 kg should be used. Dosage in paediatric patients should not exceed the maximum recommended dosage in adults (2 g 8 hourly). Experience with intramuscular administration in paediatric patients is limited. | \n
Creatinine clearance | \nRecommended Maintenance Dosage | \n|||
---|---|---|---|---|
(ml/min) | \n\n | \n | \n | \n |
> 60, Usual dose, no adjustment necessary | \n500mg 12 hourly | \n1g 12 hourly | \n2g 12 hourly | \n2g 8 hourly | \n
30-60 | \n500mg 24 hourly | \n1g 24 hourly | \n2g 24 hourly | \n1g 8 hourly | \n
11-19 | \n500mg 24 hourly | \n500mg 24 hourly | \n1g 24 hourly | \n1g 12 hourly | \n
>11 | \n250mg 24 hourly | \n250mg 24 hourly | \n500mg 24 hourly | \n1g 12 hourly | \n
Single dose vial | \nAmount of diluent to be added (ml) | \n
---|---|
500mg IV | \n5 | \n
1g IV | \n10 | \n
2g IV | \n10 | \n
500mg IM | \n1.5 | \n
1g IM | \n3.0 | \n
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