\n \nThe recommended dosage of Ledipasvir & sofosbuvir is one tablet taken orally once daily with or without food. Relapse rates are affected by baseline host and viral factors and differ between treatment durations for certain subgroups. Recommended Treatment Duration for Ledipasvir & Sofosbuvir: \n
\n \n \nPatients Type | \nTreatment Duration | \n
\n \nTreatment-naïve with or without cirrhosis | \n12 weeks | \n
\n \nTreatment-experienced without cirrhosis | \n12 weeks | \n
\n \nTreatment-experienced with cirrhosis | \n24 weeks | \n
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\nSevere Renal Impairment and End Stage Renal Disease: No dose recommendation can be given for patients with severe renal impairment or with end stage renal disease due to higher exposures of the predominant sofosbuvir metabolite. Patients with Hepatic Impairment: No dosage adjustment of Ledipasvir & Sofosbuvir is required for patients with mild, moderate or severe hepatic impairment. \n \n