About the Product

Full Description

Presentation
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Nintoin tablet: Each tablet contains Nitrofurantoin USP 100 mg
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Nintoin SR Capsule: Each capsule contains Nitrofurantoin USP 100 mg
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Nintoin Suspension: Each 5 ml suspension contains Nitrofurantoin USP 25 mg
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Description
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Nitrofurantoin is an antibacterial agent specific for urinary tract infections. Nitrofurantoin is highly soluble in urine, to which it may impart a brown color. Nitrofurantoin inactivates or alters bacterial ribosomal proteins and other macromolecules. Nitrofurantoin has been shown to be active against the following bacteria: Gram-Positive Aerobes - Staphylococcus saprophyticus, Coagulase-negative staphylococci (including Staphylococcus epidermidis), Enterococcus faecalis, Staphylococcus aureus, Streptococcus agalactiae, Group D streptococci, Viridans group streptococci. Gram-Negative Aerobes: Escherichia coli, Citrobacter amalonaticus, Citrobacter diversus, Citrobacter freundii, Klebsiella oxytoca, Klebsiella ozaenae
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Indications
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Nitrofurantoin is specifically indicated for the treatment & prophylaxis of urinary tract infections when due to susceptible strains of Escherichia coli, Enterococci, Staphylococcus aureus, Staphylococcus saprophyticus and certain susceptible strains of Klebsiella and Enterobacter species.
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Dosage & Administration
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Nitrofurantoin should be taken with food.
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Tablet:
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Adults: 50-100 mg four times a day - the lower dosage level is recommended for uncomplicated urinary tract infections.
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Children: 5-7 mg/kg/day in four divided doses (contraindicated under one month of age).
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Therapy should be continued for one week or for at least 3 days after sterility of the urine is obtained.
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For long-term suppressive therapy in adults, a reduction of dosage to 50-100 mg at bedtime may be adequate. For long-term suppressive therapy in children, doses as low as 1 mg/kg per 24 hours, given in a single dose or in two divided doses, may be adequate.
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SR Capsule:
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Adults and Children over 12 years: One 100 mg capsule every 12 hours for seven days.
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Genito-urinary surgical prophylaxis: One capsule twice daily on day of procedure and for next 3 days.
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Suspension:
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Children: 5-7 mg/kg/day in four divided doses (contraindicated under 1 month of age).
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The average dose of Nintoin suspension for pediatric patients can be calculated as follows:-
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1. For 7 to 11 kg Body Weight patient ? (2.5 ml)teaspoonfuls (4 times daily)
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2. For 12 to 21 kg Body Weight patient 1 (5 ml)teaspoonfuls (4 times daily)
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3.For 22 to 30 kg Body Weight patient 1 ? (7.5 ml)teaspoonfuls (4 times daily)
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4.For 31 to 41 kg Body Weight patient 2 (10 ml)teaspoonfuls (4 times daily)
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Therapy should be continued for one week or for at least 3 days after sterility of the urine is obtained.
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For long-term suppressive therapy in children, doses as low as 1 mg/kg per 24 hours, given in a single dose or in two divided doses, may be adequate.
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Side Effects
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The most frequent clinical adverse events are nausea, headache, and flatulence. Other less occurred adverse events are diarrhea, dyspepsia, abdominal pain, constipation, emesis, dizziness, drowsiness
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Precautions
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If acute, sub-acute, or chronic pulmonary reactions occur, Nitrofurantoin should be discontinued. Antacid preparations containing magnesium trisilicate should not be taken while taking Nitrofurantoin
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Use in Pregnancy & Lactation
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Pregnancy Category B. There are no adequate and well-controlled studies in pregnant women. This drug should be used during pregnancy only if clearly needed.
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Nitrofurantoin has been detected in human breast milk in trace amounts. Because of the potential for serious adverse reactions from Nitrofurantoin in nursing infants under one month of age, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother
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Over Dose
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Occasional incidents of acute overdosage of Nitrofurantoin have not resulted in any specific symptoms other than vomiting. Induction of emesis is recommended
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Commercial Pack
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Nintoin Tablet: Each box contains 3 blister strips of 10 tablets.
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Nintoin 50 Capsule: Each box contains 3 blister strips of 10 capsules.
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Nintoin SR Capsule: Each box contains 2 blister strips of 10 capsules.
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Nintoin Suspension: Each bottle contains 100 ml suspension.

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