About the Product

Full Description

Presentation
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Lubistone 8 Capsule: each capsule contains Lubiprostone INN 8mcg
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Lubistone 24 Capsule: each capsule contains Lubiprostone INN 24mcg
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Description
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Lubiprostone is a locally acting chloride channel activator that enhances a chloride-rich intestinal fluid secretion without altering sodium and potassium concentrations in the serum. Lubiprostone acts by specifically activating ClC-2, which is a normal constituent of the apical membrane of the human intestine.
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By increasing intestinal fluid secretion, Lubiprostone increases motility in the intestine, thereby facilitating the passage of stool and alleviating symptoms associated with chronic idiopathic constipation.
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Indications
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? Chronic Idiopathic Constipation
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? Opioid-induced Constipation (OIC) in adults with chronic non-cancer pain.
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? Irritable Bowel Syndrome with Constipation (IBS-C).
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Dosage & Administration
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Irritable Bowel Syndrome with Constipation:
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The recommended dose is 8 mcg twice daily orally with food and water.
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Dosage in patients with hepatic impairment: Dosage adjustment is not required for patients with moderately impaired hepatic function. For patients with severely impaired hepatic function, the recommended starting dose is 8 mcg once daily. If tolerated then dose can be increased to 8mcg twice
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Chronic Idiopathic Constipation and Opioid-induced Constipation:
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The recommended dose is 24 mcg twice daily orally with food and water.
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Dosage in patients with hepatic impairment: For patients with moderately impaired hepatic function, the recommended starting dose is 16 mcg twice daily. For patients with severely impaired hepatic function, the recommended starting dose is 8 mcg twice daily.
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Side Effects
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Diarrhea, full or bloated feeling or pressure in the stomach, nausea, stomach pain, swelling of abdominal or stomach area, Dyspnea
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Precautions
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Nausea: Patients taking Lubiprostone may experience nausea. Concomitant administration of food with Lubiprostone may reduce symptoms of nausea.
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Diarrhea: Lubistone should not be prescribed to patients that have severe diarrhea.
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Bowel Obstruction: In patients with symptoms suggestive of mechanical gastrointestinal obstruction, perform a thorough evaluation to confirm the absence of an obstruction prior to initiating therapy with Lubiprostone.
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Use in Pregnancy & Lactation
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Pregnancy Category C.
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It is not known whether lubiprostone is excreted in human milk. Because lubiprostone increases fluid secretion in the intestine and intestinal motility, human milk-fed infants should be monitored for diarrhea. Caution should be exercised when Lubiprostone is administered to a nursing woman.
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Drug Interaction
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There is a possibility of a dose-dependent decrease in the efficacy of Lubiprostone in patients using diphenylheptane opioids.
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Over Dose
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Adverse reactions due to overdose may include: nausea, diarrhea, vomiting, dizziness, headache, abdominal pain, flushing/hot flash, retching, dyspnea, pallor, stomach discomfort, anorexia, asthenia , chest discomfort, dry mouth, hyperhidrosis , and syncope.
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Commercial Pack
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Lubistone 8 capsule: Each box contains 2 blister strips of 10 capsules.
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Lubistone 24 capsule: Each box contains 2 blister strips of 10 capsules.

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